What the science says — and what it means for your liver health
Fatty liver disease (MASLD) affects 1 in 4 adults worldwide — and the connection to what we eat is profound. Omega-3 fatty acids are among the most studied nutritional interventions for liver health. Here is what you need to know.
Metabolic-associated steatotic liver disease (MASLD — formerly NAFLD) occurs when excess fat accumulates in liver cells, often driven by insulin resistance, visceral adiposity, and poor dietary fat quality. Left unaddressed, it can progress from simple steatosis to inflammation (MASH), fibrosis, and cirrhosis. Crucially, it is both preventable and reversible with the right metabolic interventions.
EPA & DHA suppress SREBP-1c — the key transcription factor that drives the liver to make new fat from carbohydrates.
Activates PPAR-α, shifting the liver from fat storage toward fat burning via mitochondrial beta-oxidation pathways.
Resolvin and protectin synthesis from EPA/DHA actively resolves hepatic inflammation — critical in MASH progression.
Inhibits VLDL-TG secretion and increases lipoprotein lipase activity, reducing circulating and stored liver triglycerides.
Enhances adiponectin signalling and reduces hepatic inflammation, both of which directly improve insulin receptor function.
Promotes a healthier gut microbiome composition, reducing lipopolysaccharide translocation and liver immune activation.
High-dose omega-3 supplementation (>3 g/day) may increase bleeding risk — discuss with your doctor if you are on anticoagulants. Oxidised fish oil supplements may be pro-inflammatory; choose third-party tested, high-purity products. Omega-3s are an adjunct to — not a replacement for — dietary change, exercise, and metabolic optimisation.
Book a personalised metabolic assessment with Dr. Sangeetha Thanaraj. We assess your liver health markers, omega-3 index, insulin resistance, and design an evidence-based plan tailored to you — worldwide via Zoom.
